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Sadat Najib F, Shirvani Z, Aghdaki M, Izanloo E. Application of Nanoparticles and Nanosystems in Targeted Therapy of Endometrial Cancer: A Review. pbp 2026; 8
URL: http://pbp.medilam.ac.ir/article-1-415-en.html
URL: http://pbp.medilam.ac.ir/article-1-415-en.html
1- Department of Obstetrics and Gynecology, Division of Oncology Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
2- Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran ,Zshirvani@sums.ac.ir
3- Maternal-fetal medicine Research Center, Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
4- Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
2- Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran ,
3- Maternal-fetal medicine Research Center, Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
4- Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Abstract: (37 Views)
Objective: Endometrial cancer is among the most prevalent malignancies affecting women, and conventional therapies often face limitations such as drug toxicity, cellular resistance, and restricted efficacy. Nanomedicine has emerged as a promising approach capable of significantly enhancing both therapeutic outcomes and diagnostic precision for this disease. This review aims to analyze and synthesize current knowledge on the application of nanoparticles and nanosystems in the treatment and diagnosis of endometrial cancer and endometriosis.
Methods: A comprehensive analytical review was conducted by searching PubMed, Scopus, and Web of Science databases from 2010 to 2025 using relevant keywords. Eligible studies included preclinical investigations involving in vitro and in vivo models, animal studies, and related reviews. Data were extracted qualitatively and thematically to identify the roles of nanoparticles and nanosystems in the therapeutic and diagnostic management of endometrial cancer and endometriosis.
Results: Various nanoparticles and nanosystems including NP@AZL, LDE, SPION@miR-326, CNP, FOL–PEG–PLGA + PTX, CXCR4-targeted nanotoxic agents, nMIL-100 (Fe), Porphysomes, and Tamoxifen-loaded solid lipid nanoparticles demonstrated efficacy across cellular, animal, and human models. These systems were shown to inhibit cell proliferation, induce apoptosis, reduce angiogenesis and metastasis, improve lymph node detection, and mitigate the side effects of conventional chemotherapeutics.
Conclusion: The utilization of targeted nanoparticles and nanosystems as delivery vehicles offers considerable potential to enhance therapeutic efficacy and diagnostic accuracy in endometrial cancer while minimizing systemic toxicity.
Methods: A comprehensive analytical review was conducted by searching PubMed, Scopus, and Web of Science databases from 2010 to 2025 using relevant keywords. Eligible studies included preclinical investigations involving in vitro and in vivo models, animal studies, and related reviews. Data were extracted qualitatively and thematically to identify the roles of nanoparticles and nanosystems in the therapeutic and diagnostic management of endometrial cancer and endometriosis.
Results: Various nanoparticles and nanosystems including NP@AZL, LDE, SPION@miR-326, CNP, FOL–PEG–PLGA + PTX, CXCR4-targeted nanotoxic agents, nMIL-100 (Fe), Porphysomes, and Tamoxifen-loaded solid lipid nanoparticles demonstrated efficacy across cellular, animal, and human models. These systems were shown to inhibit cell proliferation, induce apoptosis, reduce angiogenesis and metastasis, improve lymph node detection, and mitigate the side effects of conventional chemotherapeutics.
Conclusion: The utilization of targeted nanoparticles and nanosystems as delivery vehicles offers considerable potential to enhance therapeutic efficacy and diagnostic accuracy in endometrial cancer while minimizing systemic toxicity.
Type of Study: Review/Systemtic review |
Subject:
Phytomedicine
Received: 2026/02/7 | Accepted: 2026/06/6 | Published: 2026/01/1
Received: 2026/02/7 | Accepted: 2026/06/6 | Published: 2026/01/1
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